Circular eukaryotic DNA and cancer.

It seems the main place investigators “find” circular eukaryotic DNAs these days is when they’re looking at cancer cells which generate micronuclei and chromosomal rearrangements.  They call this DNA “pulverization” (see article link below). The chromosomes are literally “going nuts” with each cell division, breaking up and rearranging whatever is left. DNA replication becomes asynchronous, meaning a sizable number of these DNA chunks take on a life of their own, as if they were microorganisms in their own right. My question is simply this: How does this happen? Nobody seems to know. But I think I have an explanation for it. Check out the rest of my blog.

http://www.ncbi.nlm.nih.gov/pubmed/22258507

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About frankabernathy

I am a retired cell biologist and alumnus of Ohio State University. I became interested in chromosomes as far back as the 1960's when I wrote a term paper on the effects of radiomimetic drugs on chromosomes. I was fascinated at how they could break apart and reform new structures so easily. I became further involved in the early 1970's after taking a cytogenetics course at the University of Arkansas. I took that knowledge with me to Ohio State in 1980 where I eventually worked on my research and completed my Ph.D. dissertation, "Studies on Eukaryotic DNA Superstructure". My studies and later research suggested that the DNA within the eukaryotic chromosome is not the simple, linear molecular thread so widely suggested in all the classic textbooks published today. Instead, it may be the culmination of a geologically rapid set of endosymbiotic events where microorganisms plug into each other to create something greater than themselves. Feel free to contact me at fabernathy@sbcglobal.net.
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