What if pretty much everything you’ve been told about chromosome structure was wrong?

I am a cell biologist who received his Ph.D. in 1988 from Ohio State University and worked there for a number of years. I retired a few years back and now live in Kettering, Ohio. What I am about to tell you might astonish you if you’ve never seen this blog before. It is about chromosome structure, our chromosomes and related species. When you think of chromosomes, do you get a mental image of four hot dogs stuck together with DNA all coiled up inside them like rope? Something like this?

ChromosomeCurrent  convention says if you unravel these “hot dogs” and strip away all the non DNA components, each one of them will become extremely long strands of simple DNA. In fact, according to convention, the top and bottom “dogs” which touch each other are actually part of the same strand. That’s it. Simple, easy peasy. But what if this is completely wrong? What would be the implications for cell biology, genetics, and our most basic understanding of cancer, cell differentiation, and human development, to name just a few things? If this structure is as simple as classical biology would have us to believe, then, when it is unraveled, one would expect long meandering strands of DNA, invisible under the light microscope. What one would not expect is the following:

circles Mark TwainHow can a simple strand, or even 46 strands of DNA (in the case of humans) be incorporated into all these circular structures? They vary in size by orders of magnitude, even down to the level of the electron microscope. How can conventional science square these kinds of structures with the simple models currently used for chromosomes? How indeed! You would think scientists would be breaking their necks falling over each other to come up with some kind of explanation for this. If they are, they are keeping it a deep dark secret and have for as long as this blog has been around. And it has been around for years now.

So the next obvious question is this: Why are scientists not working on finding out how these structures are put together or asking questions about it on this blog (which is loaded with models by the way). That is the subject of a number of posts here, because the apparent lack of curiosity or follow up on these remarkable structures is just as curious as the structures themselves.


About frankabernathy

I am a retired cell biologist and alumnus of Ohio State University. I became interested in chromosomes as far back as the 1960's when I wrote a term paper on the effects of radiomimetic drugs on chromosomes. I was fascinated at how they could break apart and reform new structures so easily. I became further involved in the early 1970's after taking a cytogenetics course at the University of Arkansas. I took that knowledge with me to Ohio State in 1980 where I eventually worked on my research and completed my Ph.D. dissertation, "Studies on Eukaryotic DNA Superstructure". My studies and later research suggested that the DNA within the eukaryotic chromosome is not the simple, linear molecular thread so widely suggested in all the classic textbooks published today. Instead, it may be the culmination of a geologically rapid set of endosymbiotic events where microorganisms plug into each other to create something greater than themselves. Feel free to contact me at fabernathy@sbcglobal.net.
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