Circular DNA deletions appear widespread in mammals. So what?

Circular DNA deletions appear widespread in mammals. With further inspection, this may apply throughout the animal kingdom as well and beyond. So what gives? What is this all about? How important is this phenomenon in terms of evolution, cellular differentiation, and cancer? Doesn’t this really depend upon whether these circles are merely curiosities, trivial minor alterations in the genome, or whether they are examples of something much much more? Perhaps they are not the exceptions at all, but rather the reality of how chromosomes are actually put together.

http://news.unchealthcare.org/news/2012/march/small-dna-circles-found-outside-the-chromosomes-in-mammalian-cells-and-tissues-including-human-cells

http://www.the-scientist.com/?articles.view/articleNo/31829/title/New-Type-of-DNA-Discovered-/

CirclesCirclesThumbnails

Learn more about these circular structures by reading further into this blog.

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About frankabernathy

I am a retired cell biologist and alumnus of Ohio State University. I became interested in chromosomes as far back as the 1960's when I wrote a term paper on the effects of radiomimetic drugs on chromosomes. I was fascinated at how they could break apart and reform new structures so easily. I became further involved in the early 1970's after taking a cytogenetics course at the University of Arkansas. I took that knowledge with me to Ohio State in 1980 where I eventually worked on my research and completed my Ph.D. dissertation, "Studies on Eukaryotic DNA Superstructure". My studies and later research suggested that the DNA within the eukaryotic chromosome is not the simple, linear molecular thread so widely suggested in all the classic textbooks published today. Instead, it may be the culmination of a geologically rapid set of endosymbiotic events where microorganisms plug into each other to create something greater than themselves. Feel free to contact me at fabernathy@sbcglobal.net.
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