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In my last post (just below this one) I indicated that the linear chromosome model shown in textbooks may violate the second law of thermodynamics because of the sizes of DNA circles that would have to be stitched together from linear fragments to generate double minute chromosomes released by drugs or radiation. A possible exception to this violation may be the known fact that our chromosomes have “loops” of DNA somehow “stitched” together at the linear core of the chromosome. It is possible that the double minutes may have replicated around these loops to generate large circles of DNA without violating the second law of thermodynamics, releasing them into the nucleus as self replicating chromosomes. If so, then, upon destruction of the chromosome, it should merely fall apart into thousands of linear fragments. After all, loops are not circles, right?