Hiding in Plain Site (II)

I assume that the “woosh, over the head” factor was a bit too much in the last post. That’s ok, got to start somewhere, right? Let’s try that one more time. In fact, if I knew how to do it, I would even try a live video stream so people could ask me questions in real time. That would be cool, wouldn’t it? However, in lieu of that, here goes:

 

Some of these pictures were in the last post. The last one has been cropped. Let me try to explain what I think is going on here: In the first pic are many concentric rings containing discrete black, oblong particles. They seem to be tethered in a way that creates this bouquet effect. In the second pic, there appears to be a consolidation of particles into two larger structures, an outer ring and an inner hub. In the third picture these particles are no longer visible. Instead, you see a ring of smaller rings, some with hubs associated with them.  In the next picture, these ringed particles are being released from the larger ring. Some rings have hubs associated with them as on pictures 5 and 6. Note the well defined hub in the fifth picture. In the sixth picture the hub seems to be degenerating as the particle in the outer ring become more defined and consolidated. In the last picture the ring seems to be breaking up into discrete linear structures that look like chromosomes.

I think what you are seeing here is the development of chromosomes as they pass through the cell cycle.  When similar particles are stained with fluoresecent dye, this is what you see:

Some of the commonalities here include a large outer ring with or without a hub. The composition of this outer ring can vary from medium oblong beads to circular rings which may also contain hubs and finally to fused oblong structures that seem to break up into chromosome-like structures. Apparently the ring on a ring stage is a very delicate phase where these smaller rings can be released before they fuse together to make more oblong structures. These patterns are quite complex but there seems to be a method to all this madness.

Let me show you one last thing:

In the first picture here, the arrows point to fusions of some circles. In the second picture is evidence of an even larger fusion circle. In the last picture the circles exist as separate entities. It is quite obvious that circles may either fuse together or they may separate, depending upon the nature of their compositions which may be cell cycle dependent.  These structures are the basis for the models I present in this blog in other areas regarding cellular evolution, differentiation, and cancer. Stay tuned for more.

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About frankabernathy

I am a retired cell biologist and alumnus of Ohio State University. I became interested in chromosomes as far back as the 1960's when I wrote a term paper on the effects of radiomimetic drugs on chromosomes. I was fascinated at how they could break apart and reform new structures so easily. I became further involved in the early 1970's after taking a cytogenetics course at the University of Arkansas. I took that knowledge with me to Ohio State in 1980 where I eventually worked on my research and completed my Ph.D. dissertation, "Studies on Eukaryotic DNA Superstructure". My studies and later research suggested that the DNA within the eukaryotic chromosome is not the simple, linear molecular thread so widely suggested in all the classic textbooks published today. Instead, it may be the culmination of a geologically rapid set of endosymbiotic events where microorganisms plug into each other to create something greater than themselves. Feel free to contact me at fabernathy@sbcglobal.net.
This entry was posted in cancer, cell cycle, cellular differentiation, evolution. Bookmark the permalink.

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