Cryptic Chromosome Structure (you tube channel)

Evolution of mitosis from prokaryotes

Life in an unusual intracellular niche: a bacterial symbiont infecting the nucleus of amoebae (2014)
Evolution: Tracing the origins of centrioles, cilia, and flagella. (2011)
Bacterial “microtubules” (2011)
Endosymbiotic associations within protists. (2010)
Spirochete attachment ultrastructure: Implications for the origin and evolution of cilia. (2010)
Centrosome-associated RNA in surf clam oocytes (2006)
Comparative rates of evolution in endosymbiotic nuclear genomes  (2006)
Scientists prove that parts of the cell nuclei are not arranged at random. (2006)
Motor Proteins and endosymbionts (2005)
Endosymbiotic Bacteriodales bacteria of the flagellated protist Pseudotrichonympha grassii in the gut of the termite Coptotermes formosanus. (2005)
The ring of life provides evidence for a genome fusion origin of eukaryotes (2004)
Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes (2004)
Genome Evolution in Bacterial Endosymbionts of Insects. (2002)
Facultative bacterial endosymbionts benefit pea aphids Acyrthosiphon pisum during heat stress. (2002)
MICROSPORIDIA: Biology Biology and Evolution of Highly Reduced Intracellular Parasites (2002)
Genome Evolution in Bacterial Endosymbionts of Insects. (2002)
Four intracellular genomes direct weevel biology: Nuclear, mitochondrial, principal endosymbiont, and Wolbachia. (1999)
Archaea and the prokaryote-to-eukaryote transition. (1997)
Microtubules of the flagellar apparatus are active during prey capture in the chrysophycean alga Epipyxis pulchra (1992)

Eukaryotic composite centrosomes

Mitotic spindle multipolarity without centrosome amplification. (2014)

Models for wheel and hub photomicrographs

(click each thumbnail for more information)

fig. 28

How multiorigin replicons may have evolved via transposon insertions into eukaryotic chromosomes (Fig 27, 28, 29, 36, Website, 1999) (click any image to enlarge)

Bacteria may have multiple replication origins (2015)
Revealing Long-Range Interconnected Hubs in Human Chromatin Interaction Data Using Graph Theory (2013) (master replication origins)
Origin pairing (‘handcuffing’) as a mode of negative control of P1 plasmid copy number.  (2001)
Interactions of Epstein-Barr virus origins of replication with nuclear matrix in the latent and in the lytic phases of viral infection. (1999)

 Fig 17Fig 18

Undifferentiated DNA Megacluster (left, Fig 17, Website, 1999) Differentiated DNA Megacluster (right, Fig 18, Website, 1999)
(click either image to enlarge)

Mapping of a replication origin within the promoter region of two unlinked, abundantly transcribed actin genes of Physarum polycephalum. (1996) 


How RNA is transcribed and processed from a differentiated  DNA megacluster (Fig 23, 24, Website, 1999), (click any image to enlarge). The second image illustrates intron lariats. The third image illustrates linear introns.


(click to enlarge) Model of a eukaryotic chromosome based upon DNA megaclusters incorporated via hierarchical endosymbiosis, (Figure 46a,b, website 1999)


(click to enlarge) diagram of Figure 46b (above) showing one possible transcriptional pathway, (Figure 46c, website 1999)

(click to enlarge) explanation for how methods used to generate linear fragments for genomic sequencing can lead to erroneous conclusions about the complexity of  chromosomal DNA superstructure

rippled chromatincircular arrays

(click to enlarge) Above model  is interpreted from reference below (Figure C, p 86)

Higher-order structure of chromatin from resting cells I. Cavazza B., et al., 1983. J. Cell Sci. 62:81-102

(click to enlarge) This model illustrates how a complex DNA circular element may supercoil and condense into a chromosomal subunit subsequent to DNA replication along the length of the element.  The final figure in this model has been seen and published in a reference. When I find the reference, I will add a link to it here.



3 Responses to Models

  1. nice work, i have linked ur page as my evolution resource on my blog. its on my latest post.

  2. Pingback: Chromonomes? | Evolution Turned Upside Down

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