## Was Isaac Newton Wrong About Chromosomes?

Ok, I know this is bordering on bait and switch, but give me a break, ok? I have to compete with cute cats, the deep state, the end of the world, and people who can juggle fireballs while playing Beethoven’s Fifth. Well, perhaps I am hyperbolizing just a bit, but you get my drift. I know, I know. Isaac Newton didn’t even know what a chromosome was when he came up with his three laws of thermodynamics. Please don’t yawn, I’ll get right to the point here. One of his laws involved something called entropy or the state of disorder in a defined system.

NO YAWNING! THERE’S A QUIZ AND HEADS WILL ROLL!

Simply put, this law states that all systems tend to go from a defined state of order to one of more disorder. In other words, chaos reigns, at least where this law is concerned, anyway.  For example, if you hit a rock with a hammer it shatters into pieces. You never see the reverse do you? I mean have you ever seen a hammer hit a bunch of rock fragments which come together into a single rock as a result? I will assume I made my point here and move on before you go comatose on me. So many cat videos, so little time…

So here is the point I’m trying to make here. Let’s say you have a very, very, very long string floating in a viscous liquid and you cut it into various sizes along its length. The ends of each of these fragments have the capacity to stick together to form circles. However, compared to these “sticky” ends these fragments are enormously long. The odds of these ends ever finding each other in this three dimensional spaghetti-like soup of a mixture is very remote. This may be complicated by the fact that other fragments may have sticky ends that can link up to other fragments, making them longer instead of circular.

Does this sound kind of ridiculous? Well, perhaps that’s because it is. Wouldn’t it make more sense that instead of long random linear fragments forming circles, the circles were already there to begin with? If this makes sense, then, the long held notion that chromosomes are long strings of DNA makes no sense in light of what I discovered over 30 years ago.