The facts still stand: How do you generate thousands of circles with orders of magnitude size differences from 40 linear mouse chromosomes? The most obvious answer is that they were already present in a cryptic form (click photos to enlarge).
Degrading mouse cells, 400x magnification
What do mouse chromosomes look like under “normal” conditions? Check out this link: mouse chromosome.
How do you create a simple linear stretch of DNA that goes on and on, like some kind of endlessly meandering oil pipeline?
Well, first of all, you beat the living hell out of it so it breaks up into fragments. Next, get rid of any nonlinear fragments because, face it, they can’t be sequenced anyway. This is most easily done by throwing out the phenol phase used for DNA extraction which may contain any troublesome DNA/protein/lipid etc interactions. Next, take what’s left (linear DNA fragments) and artificially splice them together in your mind using overlapping sequences. If this doesn’t always work, just extrapolate until it does. Voilà! We now have a nice, neat (if somewhat boring) endlessly linear, stretch of DNA.
I find it amazing that scientists are able to tinker with DNA to generate an apparent infinite variety of two and three dimensional objects that are incredibly complex, detailed, and highly symmetrical, some like snowflakes. You can learn more about this nanotechnology by clicking on the link below:
So my question is this: Why is it so difficult to connect the dots here? If man can generate such a wide array of DNA superstructures, why can’t nature? More to the point, the ability to exploit DNA in such a fashion is more than mere coincidence. Nature has been using complex DNA superstructures for eons to generate the chromosomes necessary for the complexity of multicellular life that now exists on this planet.
Hypothetical natural DNA “origami” (circa 1991)
Learn more about natural DNA “origami” by reviewing this blog or contacting Dr. Frank Abernathy: email@example.com
This link is very interesting and at first glance seems totally unrelated to what usually appears on my blog. However, though the discovery is quite fascinating and worth reviewing, I mention it here for a different reason: The initial reaction of the scientific community to what they regard as heresy.
Horizontal gene transfer in this blog suggests that our very chromosomes were constructed by it. Is this a process that happened eons ago and is now relegated to the dustbin of history, occurring only within primitive life forms like bacteria?
This video was sent to Bioscapes at their request for their 2014 presentations. It provides technical data on how the substructures shown in this blog were prepared. Additional information can be provided by contacting Dr. Abernathy at ResearchGate or by firstname.lastname@example.org.